“In My Grow Show” hosted by Alex Robles: Ep. 40

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CBG and a conversation with Kristen and Felipe

11/2018

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Click here for seed menu “I Love Growing Marijuana”

Show Notes:  Thank you for showing up.   

I need a new LED light bulb

Strain of the Week: Is the cool one.  It’s a cross of “3rd Dimension and Hit It Once”.  I breed this for its ease of growth in hot summer weather.  Fruity smell and taste, uplifting and energizing. It got me really high and kept me there for a long time.  I haven’t grown it in awhile, i forgot how good it was. I’m going to pop more seeds soon for it.

Report from the cannabis front line

-U.S. Senate Majority Leader Mitch McConnell (R-KY) issued a “guarantee” that hemp legalization will be in the finalized Farm Bill. “If there’s a Farm Bill, it’ll be in there, I guarantee that,” he told reporters.

-Texas: House Bill 63 has been pre-filed by Rep. Joe Moody that seeks to replace current criminal sanctions for marijuana possession with a civil penalty, punishable by a fine only with no jail or criminal record.

Senate Bill 90 has been pre-filed by Sen. Jose Menendez that seeks to expand the Texas Compassionate Use Program (TCUP) and make it more inclusive and compassionate for patients.

-It’s possible that Massachusetts recreational marijuana sales could begin on Sunday. The state’s top regulator said sales will likely start in “a week plus or minus maybe a couple of days longer than that.”

-The Vermont marijuana legalization study committee’s taxation and regulation subcommittee plans to recommend a 26% or 27% tax rate on sales

Mexico’s New Government:  New government signals legalization https://www.npr.org/2018/11/14/667699301/mexico-hopes-to-legalize-marijuana

CBG:

Biosynthesis is the combination of chemical compounds to form new chemical compounds. In the case of the cannabis plant, the important chemicals to remember are:

  • Geranyl pyrophosphate (GPP or sometimes GDP).
  • Olivetolic acid (OLA).

These two chemicals are the building blocks of all 113 cannabinoids we mentioned earlier.

In raw cannabis plants, geranyl pyrophosphate and olivetolic acid combine to produce cannabigerolic acid (CBGA).

    • Cannabigerol, or CBG, is a non-psychoactive cannabinoid typically most abundant in low-THC, high-CBD cannabis strains, including hemp.

      Because it is present in low levels (usually less than 1%) in most cannabis strains, CBG is considered a minor cannabinoid. Amazingly, however, THC and CBD start out as CBG—it’s the chemical parent of THC and CBD. Cannabis plants produce cannabigerolic acid (CBGA), the precursor to the three main cannabinoid lines: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).

  • Specific enzymes in the plant break CBGA down and “direct” it toward one of the three lines. The acids are exposed to ultraviolet light or heat, and they become the cannabinoids we know: THC and CBD. In most strains, CBGA is immediately converted to either THCA or CBDA. Thus, more THC means less CBG and CBD (and vice versa). CBG is found mainly in hemp products, High CBD strains, on the other hand, contain much higher concentrations of this essential cannabinoid.
  • While most strains of cannabis are less than 10% CBG, industrial hemp strains test much higher. They have been tested as high as 94% CBG with as low as 0.001% THC.  Further studies have shown that this phenomenon may be due to a recessive gene. This gene, they think is responsible for keeping the plant from making one of the cannabinoid synthases (what converts CBGA to one of the major branches).
  • To obtain higher yields of CBG, breeders are experimenting with genetic manipulation and cross-breeding of plants. Scientists can also extract higher levels of CBG from budding plants by pinpointing the optimum extraction time, about six weeks into an eight week flowering cycle. A medicinal strain called Bediol is produced in this fashion by the Dutch company Bedrocan BV Medicinal Cannabis.

CBG has been found to act on very specific physiological systems and problems, and results for medicinal use are promising:

  • Endocannabinoid receptors are prevalent in eye structures, and interestingly, CBG is thought to be particularly effective in treating glaucoma because it reduces intraocular pressure. It is a powerful vasodilator and has neuroprotective effects to boot.
  • In animal experiments involving mice, CBG was found to be effective in decreasing the inflammation characteristic of inflammatory bowel disease.
  • In a recent 2015 study, CBG was shown to protect neurons in mice with Huntington’s disease, which is characterized by nerve cell degeneration in the brain.
  • CBG is showing great promise as a cancer fighter. Specifically, CBG was shown to block receptors that cause cancer cell growth. In one such study, it was shown to inhibit the growth of colorectal cancer cells in mice, thereby slowing colon cancer growth. CBG inhibited tumors and chemically-induced colon carcinogenesis, therefore demonstrating a very exciting possibility for a cure for colorectal cancer.
  • European research shows evidence that CBG is an effective antibacterial agent, particularly against methicillin-resistant Staphylococcus aureus (MRSA) microbial strains resistant to several classes of drugs. Since the 1950s, topical formulations of cannabis have been effective in skin infections, but researchers at the time were unaware of the plant’s chemical composition.
  • In a very recent 2017 study, researchers showed that a form of CBG purified to remove delta-9 THC was a very effective appetite stimulant in rats. This could be a good non-psychotropic option for cachexia, the muscle wasting and severe weight loss seen in late stage cancer and other diseases.
  • In a study that looked at the effects of five different cannabinoids on bladder contractions, CBG tested best at inhibiting muscle contractions, so it may be a future tool in preventing bladder dysfunction disorders.

CBG does not have any side effects when taken in therapeutic doses. The key words there are “therapeutic doses.” You can experience negative side effects if you consume too much of any substance…even water.

Thankfully, CBG only becomes a problem when taken in excess of 300 milligrams per kilogram of body weight.

Resource Articles

https://www.medicaljane.com/2013/08/03/cannabigerol-cbg-is-a-minor-cannabinoid-with-major-impact/

https://www.leafly.com/news/cannabis-101/what-is-cbg-cannabinoid

https://honestmarijuana.com/cbg/

Conversation with Kristen and Felipe

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Music:

Bensound:– Jazz Piano

Gnawledge-Flamencologa

-El mansion de Potemkin

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